منابع مشابه
Functional binding of the "TATA" box binding component of transcription factor TFIID to the -30 region of TATA-less promoters.
Many viral and cellular promoters transcribed in higher eukaryotes by RNA polymerase II lack obvious A+T-rich sequences, called "TATA" boxes, that bind the transcription factor TFIID. One such TATA-less promoter, the simian virus 40 major late promoter, contains a genetically important sequence element 30 base pairs upstream of its transcription initiation site that has no obvious sequence simi...
متن کاملIdentification and Distinct Regulation of Yeast TATA Box-Containing Genes
Despite being one of the first eukaryotic transcriptional regulatory elements identified, the sequence of a native TATA box and its significance remain elusive. Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and arrived at the consensus TATA(A/T)A(A/T)(A/G). Approximately 20% of yeast genes contain a TATA box. Strikingly, TATA box-containing genes are asso...
متن کاملCore promoter-specific gene regulation: TATA box selectivity and Initiator-dependent bi-directionality of serum response factor-activated transcription.
Gene-specific activation by enhancers involves their communication with the basal RNA polymerase II transcription machinery at the core promoter. Core promoters are diverse and may contain a variety of sequence elements such as the TATA box, the Initiator (INR), and the downstream promoter element (DPE) recognized, respectively, by the TATA-binding protein (TBP) and TBP-associated factors of th...
متن کاملTATA Box Mimicry by TFIID Autoinhibition of Pol II Transcription
TATA Box Mimicry by TFIID: Minireview Autoinhibition of Pol II Transcription with formation of a stable TBP-TATA element complex. Deletion studies with dTAF II 230 mapped the autoinhibi-tory activity to the first 81 amino acids (reviewed in Liu In eukaryotes, RNA polymerase II (pol II) is responsible for transcribing nuclear genes encoding the messenger RNAs and several small nuclear RNAs. Like...
متن کاملOptimizations of SiRNA Design for the Activation of Gene Transcription by Targeting the TATA-Box Motif
Small interfering RNAs (siRNAs) are widely used to repress gene expression by targeting mRNAs. Some reports reveal that siRNAs can also activate or inhibit gene expression through targeting the gene promoters. Our group has found that microRNAs (miRNAs) could activate gene transcription via interaction with the TATA-box motif in gene promoters. To investigate whether siRNA targeting the same re...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1989
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.86.20.7785